The crash happened in Haycock Township, located in Bucks County, around 11:40 p.m. Friday, June 4, Pennsylvania State Police said.
Initial reports say the two vehicles involved, each carrying two people, caught fire after crashing.
The driver of a Chevrolet Equinox, a 26-year-old man from Ossining, was airlifted with serious injuries. His passenger, a 24-year-old woman from Rockaway, New Jersey, died.
The two occupants of the Lexus ES 330 both died, and they were identified as 25- and 26-year-old men from Ottsville, Pennsylvania, and Quakertown, Pennsylvania.
The identities of those involved have not yet been released.
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